T cell Proliferative Response to Type II collagen is related to Inflammatory Process and Joint Damage in Rheumatoid Arthritis / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 106-116, 2002.
Artículo
en Coreano
| WPRIM
| ID: wpr-222565
ABSTRACT
OBJECTIVE:
To investigate the role of T cell responses to type II collagen (CII) in disease progression in rheumatoid arthritis (RA).METHODS:
T cell proliferative responses to bovine CII by peripheral blood mononuclear cells (PBMC) from early RA patients (duration or =2) had higher levels of CRP and ESR than those (n=21) not showing T cell responses. The number of damaged joints (by Steinbrocker's method) and damaged joint scores (by Sharp's method) were significantly higher in patients with positive T cell responses than in those without. The joint space narrowing scores correlated well with T cell responsiveness to CII. Patients (n=15) with both positive T cell responses and RA-susceptible allotypes, HLA-DR1 or DR4, had greater damaged joint scores than the rest of patients (n=24).CONCLUSION:
T cell proliferative responses to CII are associated with inflammatory activity and radiographic severity in RA. Our data suggest that CII reactive T cells may play an important role in the pathogenic process of joint damage.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Artritis Reumatoide
/
Sedimentación Sanguínea
/
Proteína C-Reactiva
/
Linfocitos
/
Linfocitos T
/
Antígeno HLA-DR1
/
Estudios Transversales
/
Progresión de la Enfermedad
/
Colágeno Tipo II
/
Mano
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
Límite:
Humanos
Idioma:
Coreano
Revista:
The Journal of the Korean Rheumatism Association
Año:
2002
Tipo del documento:
Artículo
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