Interleukin-8 Expression in Psoriatic Skin of Different Disease Activities / 대한피부과학회지
Korean Journal of Dermatology
;
: 339-345, 1999.
Artículo
en Coreano
| WPRIM
| ID: wpr-222590
ABSTRACT
Psoriasis is a relatively common disorder that affects at least 1-2% of the population, however, the pathogenesis is not fully understood yet. Histopathologically, psoriatic lesion is characterized by hyperplasia of keratinocyte, intraepidermal neutrophil accumulation and activated T lymphocyte infiltration in the dermis. Among many cytokines, IL-8 is known to play a role for the activation and migration for neutrophil and T lymphocyte and for the proliferation of keratinocyte. We performed immunohistochemical staining with anti-IL-8 monoclonal antibody for the active lesion, stable lesion and normal-looking skin of ten psoriatic patients and ten healthy controls. Strong expression of IL-8 in the epidermis and dermis was noted from the active as well as stable psoriatic skins. In the normal-looking skin of the psoriatic patients, only faint expression which is not different from healthy control skin, was noted. These observations indicate that the expression of IL-8 is increased in psoriatic lesion, and IL-S is important for the initiation and maintenance of psoriasis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Psoriasis
/
Piel
/
Linfocitos
/
Queratinocitos
/
Citocinas
/
Interleucina-8
/
Dermis
/
Epidermis
/
Hiperplasia
/
Neutrófilos
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Año:
1999
Tipo del documento:
Artículo
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