The Expression of Keratinocyte Growth Factor mRNA in Dendritic Epidermal T Cell / 대한피부과학회지
Korean Journal of Dermatology
;
: 290-296, 1999.
Artículo
en Coreano
| WPRIM
| ID: wpr-222597
ABSTRACT
BACKGROUND:
The keratinocyte growth factor(KGF) is a recently identified mitogen for epithelial cells produced by nomal stromal fibroblasts. ln the skin, KGF has been shown to stimulate keratinocyte proliferation and differentiatian. Dendritic epidermal T cells(DETC) are skin-specific members of the epithelial y 8 T-cell family that reside normally in the murine epidermis. The DETCs recognize antigen expressed by damaged or diseased neighboring keratinoctyes and consequently secrete cytokines sueh as IFN- y, lL-2, IL-4, GM-CSF.OBJECTIVE:
The purpose of this study was to observe the expression of KGF mRNA in keratinocyte and DETC as well as to investigate the cytokine-mediated intercellular communication between kerati- nocyte and DETC.METHODS:
Using a RT-PCR(reverse transcription-polymerase chain reaction), we examined the expression of KGF mRNA in keratinocyte and DETC, and compared the level of KGF mRNA between resting and activated DETC with Con-A (concanavalin A).
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Piel
/
ARN Mensajero
/
Linfocitos T
/
Queratinocitos
/
Citocinas
/
Factor Estimulante de Colonias de Granulocitos y Macrófagos
/
Interleucina-4
/
Epidermis
/
Células Epiteliales
/
Factor 7 de Crecimiento de Fibroblastos
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Año:
1999
Tipo del documento:
Artículo
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