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Fusobacterium nucleatum GroEL signaling via Toll-like receptor 4 in human microvascular endothelial cells
International Journal of Oral Biology ; : 130-136, 2012.
Artículo en Inglés | WPRIM | ID: wpr-222608
ABSTRACT
The GroEL heat-shock protein from Fusobacterium nucleatum, a periodontopathogen, activates risk factors for atherosclerosis in human microvascular endothelial cells (HMEC-1) and ApoE-/- mice. In this study, we analyzed the signaling pathways by which F. nucleatum GroEL induces the proinflammatory factors in HMEC-1 cells known to be risk factors associated with the development of atherosclerosis and identified the cellular receptor used by GroEL. The MAPK and NF-kappaB signaling pathways were found to be activated by GroEL to induce the expression of interleukin-8 (IL-8), monocyte chemoattractant protein 1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), E-selectin, and tissue factor (TF). These effects were inhibited by a TLR4 knockdown. Our results thus indicate that TLR4 is a key receptor that mediates the interaction of F. nucleatum GroEL with HMEC-1 cells and subsequently induces an inflammatory response via the MAPK and NF-kappaB pathways.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Periodontitis / Tromboplastina / Factores de Riesgo / Interleucina-8 / FN-kappa B / Fusobacterium nucleatum / Molécula 1 de Adhesión Intercelular / Molécula 1 de Adhesión Celular Vascular / Quimiocina CCL2 / Selectina E Tipo de estudio: Estudio de etiología / Estudio pronóstico / Factores de riesgo Límite: Animales / Humanos Idioma: Inglés Revista: International Journal of Oral Biology Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Periodontitis / Tromboplastina / Factores de Riesgo / Interleucina-8 / FN-kappa B / Fusobacterium nucleatum / Molécula 1 de Adhesión Intercelular / Molécula 1 de Adhesión Celular Vascular / Quimiocina CCL2 / Selectina E Tipo de estudio: Estudio de etiología / Estudio pronóstico / Factores de riesgo Límite: Animales / Humanos Idioma: Inglés Revista: International Journal of Oral Biology Año: 2012 Tipo del documento: Artículo