Intravenous Anti-D immunoglobulin treatment of adult chronic immune thrombocytopenic purpura (ITP) / 대한내과학회지
Korean Journal of Medicine
;
: 176-180, 2008.
Artículo
en Coreano
| WPRIM
| ID: wpr-222780
ABSTRACT
BACKGROUND/AIMS:
Immune thrombocytopenic purpura (ITP) is an autoimmune disease that is mediated by anti-platelet antibodies. Based on the pathogenesis of ITP we evaluated the efficacy of intravenous anti-D immunoglobulin for adult chronic ITP.METHODS:
Fourteen patients (4 without splenectomy and 10 with splenectomy) with refractory chronic ITP were treated with 50-70 microgram/kg of intravenous anti-D immunoglobulin only once. Treatment effects were evaluated by measuring the platelet counts and hemoglobin levels.RESULTS:
Five patients (36%) showed a response; improvement in the platelet count lasted for on average 7 days (range 2~24 days). There were no serious adverse effects.CONCLUSION:
Anti-D immunoglobulin, which is associated with an Fc receptor blockade, appeared to be safe and effective for the treatment of adults with chronic ITP. Further studies are needed to confirm these findings and define further potentially effective treatment protocols with intravenous anti-D immunoglobulin.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Recuento de Plaquetas
/
Enfermedades Autoinmunes
/
Esplenectomía
/
Hemoglobinas
/
Inmunoglobulinas
/
Receptores Fc
/
Protocolos Clínicos
/
Púrpura Trombocitopénica Idiopática
/
Globulina Inmune rho(D)
/
Isoanticuerpos
Tipo de estudio:
Guía de Práctica Clínica
Límite:
Adulto
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Año:
2008
Tipo del documento:
Artículo
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