Nuclear Receptors Resolve Endoplasmic Reticulum Stress to Improve Hepatic Insulin Resistance
Diabetes & Metabolism Journal
;
: 10-19, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-222887
ABSTRACT
Chronic endoplasmic reticulum (ER) stress culminating in proteotoxicity contributes to the development of insulin resistance and progression to type 2 diabetes mellitus. Pharmacologic interventions targeting several different nuclear receptors have emerged as potential treatments for insulin resistance. The mechanistic basis for these antidiabetic effects has primarily been attributed to multiple metabolic and inflammatory functions. Here we review recent advances in our understanding of the association of ER stress with insulin resistance and the role of nuclear receptors in promoting ER stress resolution and improving insulin resistance in the liver.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Resistencia a la Insulina
/
Receptores Citoplasmáticos y Nucleares
/
Diabetes Mellitus Tipo 2
/
Retículo Endoplásmico
/
Respuesta de Proteína Desplegada
/
Estrés del Retículo Endoplásmico
/
Insulina
/
Hígado
Idioma:
Inglés
Revista:
Diabetes & Metabolism Journal
Año:
2017
Tipo del documento:
Artículo
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