Correlation between Serum Cystatin C Levels and Clinical Parameters in Children with Urinary Tract Infections
Journal of the Korean Society of Pediatric Nephrology
;
: 85-91, 2014.
Artículo
en Coreano
| WPRIM
| ID: wpr-223759
ABSTRACT
PURPOSE:
We aimed to investigate the correlation between serum cystatin C and clinical manifestations in pediatric patients with urinary tract infections (UTIs).METHODS:
We studied 137 patients admitted with UTIs from June 2012 to May 2014. Depending on the presence of renal cortical defects on 99m Tc-dimercaptosuccinic acid scintigraphy, we classified patients into non-renal and renal defect groups. Laboratory and clinical parameters were analyzed, including the levels of serum cystatin C. The correlation between cystatin C and other variables was assessed.RESULTS:
Serum cystatin C levels did not differ between the non-renal and renal defect groups. In both groups, serum cystatin C levels increased after 4-5 days of treatment, compared with the level at admission (P<0.001). However, mean levels were within normal ranges. The concentration of serum cystatin C positively correlated with serum creatinine and negatively correlated with age (P<0.05). In contrast, there was no correlation between serum cystatin C and other variables.CONCLUSION:
Serum cystatin C does not appear to be a useful biomarker for renal defects in pediatric patients with UTIs. Further studies are necessary to conclude whether serum cystatin C is helpful in predicting deterioration in renal function in pediatric patients with UTIs.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pielonefritis
/
Valores de Referencia
/
Infecciones Urinarias
/
Cintigrafía
/
Creatinina
/
Cistatina C
Tipo de estudio:
Estudio pronóstico
Límite:
Niño
/
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Society of Pediatric Nephrology
Año:
2014
Tipo del documento:
Artículo
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