The Antipruritic Effect of 5% Doxepin Cream on Korean Patients with Eczematous Dermatitis / 대한피부과학회지
Korean Journal of Dermatology
;
: 675-680, 2006.
Artículo
en Coreano
| WPRIM
| ID: wpr-223817
ABSTRACT
BACKGROUND:
Eczematous dermatitis is associated with severe pruritus, but there are only a few effective treatment modalities. Preliminary studies suggest that topical application of doxepin cream is effective in the treatment of eczematous dermatitis.OBJECTIVE:
This study was undertaken to evaluate the efficacy and safety of topical 5% doxepin cream in reducing ruritus associated with eczematous dermatitis in Korea.METHODS:
A total of 62 patients with eczematous dermatitis, who daily experienced severe pruritus for at least 1 week, were enrolled in the study. Five percent doxepin cream was applied twice a day on the baseline visit, and four times daily for up to 7 days. We evaluated pruritus scores using visual analog scales, which consisted of a 100-mm horizontal line labeled "no itch" and "worst itch imaginable" at opposite ends.RESULTS:
Pruritus scores evaluated by patients revealed significantly-better improvement on each visit day. Furthermore, there was a significant decrease in the pruritus scores and erythema evaluated by physicians on each visit day. Furthermore, the most common adverse effects were a stinging sensation and aggravation of erythema at the site of application.CONCLUSION:
Five percent doxepin cream is safe and effective in reducing pruritus in patients with eczematous dermatitis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Prurito
/
Sensación
/
Mordeduras y Picaduras
/
Doxepina
/
Eccema
/
Eritema
/
Escala Visual Analógica
/
Corea (Geográfico)
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Año:
2006
Tipo del documento:
Artículo
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