Comparative Vestibulotoxicity of Different Aminoglycosides in the Guinea Pigs
Yonsei Medical Journal
;
: 517-522, 2003.
Artículo
en Inglés
| WPRIM
| ID: wpr-224217
ABSTRACT
The histopathological alterations in the vestibule due to aminoglycosides are well defined. Although there are reports comparing the vestibulotoxic effects of the many aminoglycosides, this is the first study to compare the effects of the most commonly used aminoglycosides i.e., streptomycin, gentamicin, amikacin and netilmicin administered both transtympanically and systemically. The transtympanic and systemic administration of each aminoglycoside caused similar histopathological alterations in the vestibule. The most severe degeneration in the cristae ampullaris, utriculus and sacculus was observed after streptomycine administration. The severity of the vestibular damage in terms of magnitude was in the order of streptomycine, gentamicin, amikacin, and netilmicin.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Membrana Timpánica
/
Estudio Comparativo
/
Amicacina
/
Gentamicinas
/
Netilmicina
/
Estreptomicina
/
Vestíbulo del Laberinto
/
Cobayas
/
Inyecciones Intraperitoneales
Límite:
Animales
Idioma:
Inglés
Revista:
Yonsei Medical Journal
Año:
2003
Tipo del documento:
Artículo
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