A case of myeloid neoplasm with the PDGFRB rearrangement and eosinophilia / 대한내과학회지
Korean Journal of Medicine
;
: 386-390, 2010.
Artículo
en Coreano
| WPRIM
| ID: wpr-224540
ABSTRACT
Myeloid neoplasm with the platelet-derived growth factor receptor beta (PDGFRB) rearrangement is a myeloproliferative neoplasm. Patients with this disease often have prominent eosinophilia or monocytosis and the presence of t(5;12)(q31~33;p12) or a variant translocation with expression of an ETV6-PDGFRB fusion gene or the PDGFRB rearrangement. We report an 82-year-old woman with a myeloid neoplasm, with the PDGFRB rearrangement, who presented with a dry cough, eosinophilia and thrombocytosis. The chromosome study of the bone marrow showed 46,XX,ins(1;5)(q22;q33q13.3), and fluorescence in situ hybridization (FISH) analysis revealed rearrangement of the PDGFRB gene. The patient was successfully treated with low-dose imatinib.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Piperazinas
/
Pirimidinas
/
Trombocitosis
/
Benzamidas
/
Médula Ósea
/
Receptores del Factor de Crecimiento Derivado de Plaquetas
/
Hibridación in Situ
/
Tos
/
Receptor beta de Factor de Crecimiento Derivado de Plaquetas
/
Eosinofilia
Límite:
Anciano
/
Aged80
/
Femenino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Año:
2010
Tipo del documento:
Artículo
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