Multiple Endocrine Neoplasia Type 1 Presenting as Hypoglycemia due to Insulinoma
Journal of Korean Medical Science
;
: 1003-1006, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-224843
ABSTRACT
Multiple endocrine neoplasia (MEN) mutation is an autosomal dominant disorder characterized by the occurrence of parathyroid, pancreatic islet, and anterior pituitary tumors. The incidence of insulinoma in MEN is relatively uncommon, and there have been a few cases of MEN manifested with insulinoma as the first symptom in children. We experienced a 9-year-old girl having a familial MEN1 mutation. She complained of dizziness, occasional palpitation, weakness, hunger, sweating, and generalized tonic-clonic seizure that lasted for 5 minutes early in the morning. At first, she was only diagnosed with insulinoma by abdominal magnetic resonance images of a 1.3 × 1.5 cm mass in the pancreas and high insulin levels in blood of the hepatic vein, but after her father was diagnosed with MEN1. We found she had familial MEN1 mutation, and she recovered hyperinsulinemic hypoglycemia after enucleation of the mass. Therefore, the early genetic identification of MEN1 mutation is considerable for children with at least one manifestation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Pancreáticas
/
Linaje
/
Convulsiones
/
Análisis Mutacional de ADN
/
Imagen por Resonancia Magnética
/
Secuencia de Bases
/
Proteínas Proto-Oncogénicas
/
Neoplasia Endocrina Múltiple Tipo 1
/
Polimorfismo de Nucleótido Simple
/
Alelos
Tipo de estudio:
Estudio pronóstico
Límite:
Niño
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
2016
Tipo del documento:
Artículo
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