Molecular Dimensions of Gastric Cancer: Translational and Clinical Perspectives
Journal of Pathology and Translational Medicine
;
: 1-9, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-225237
ABSTRACT
Gastric cancer is a global health burden and has the highest incidence in East Asia. This disease is complex in nature because it arises from multiple interactions of genetic, local environmental, and host factors, resulting in biological heterogeneity. This genetic intricacy converges on molecular characteristics reflecting the pathophysiology, tumor biology, and clinical outcome. Therefore, understanding the molecular characteristics at a genomic level is pivotal to improving the clinical care of patients with gastric cancer. A recent landmark study, The Cancer Genome Atlas (TCGA) project, showed the molecular landscape of gastric cancer through a comprehensive molecular evaluation of 295 primary gastric cancers. The proposed molecular classification divided gastric cancer into four subtypes Epstein-Barr virus-positive, microsatellite unstable, genomic stable, and chromosomal instability. This information will be taken into account in future clinical trials and will be translated into clinical therapeutic decisions. To fully realize the clinical benefit, many challenges must be overcome. Rapid growth of high-throughput biology and functional validation of molecular targets will further deepen our knowledge of molecular dimensions of this cancer, allowing for personalized precision medicine.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Gástricas
/
Características de la Población
/
Biología
/
Incidencia
/
Clasificación
/
Genoma
/
Repeticiones de Microsatélite
/
Inestabilidad Cromosómica
/
Asia Oriental
/
Investigación Biomédica Traslacional
Tipo de estudio:
Estudio de incidencia
/
Estudio pronóstico
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Journal of Pathology and Translational Medicine
Año:
2016
Tipo del documento:
Artículo
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