Allele Distribution and Frequency of Human Surfactant Protein-A1 in Korean Neonates
Journal of the Korean Pediatric Society
;
: 1497-1502, 2002.
Artículo
en Coreano
| WPRIM
| ID: wpr-225410
ABSTRACT
PURPOSE:
We evaluated allele frequencies and distribution of surfactant protein A1(SP-A1) in Korean neonates in order to estimate prevalence of RDS to find out new SP-A alleles, and to establish new steroid therapy.METHODS:
Genomic DNA was extracted from 100 neonates and served as a template in PCR for genotype analysis. SP-A gene-specific amplications and gene-specific allele determinations were performed using PCR-RFLP methods.RESULTS:
The distribution for the alleles of the SP-A1 gene in the study population were 6A, 6A(2), 6A(3), 6A(4), 6A(8), 6A(9), 6A(10), 6A(11), 6A(12), 6A(13), 6A(14), 6A(15), 6A(16), 6A(17), 6A(18), 6A(20). The specific frequencies for the alleles of the SP-A1 gene in the study population were 6A(2)=21%, 6A(3)=45%, 6A(4)=11%, 6A(8)=9%, 6A(14)=8%.CONCLUSIONS:
The frequency of 6A3 was higher than the other SP-A1 alleles in Korean neonates. This finding suggests that the prevalence of RDS in Korea may be low compared with other countries. However, this finding also suggests that Korean neonates have a high risk of infection.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
ADN
/
Reacción en Cadena de la Polimerasa
/
Prevalencia
/
Alelos
/
Frecuencia de los Genes
/
Genotipo
/
Corea (Geográfico)
Tipo de estudio:
Estudio de prevalencia
Límite:
Humanos
/
Recién Nacido
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
Journal of the Korean Pediatric Society
Año:
2002
Tipo del documento:
Artículo
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