Deletion of Rb1 gene in late osteosarcoma from survivor of unilateral retinoblastoma: a case report
Journal of Korean Medical Science
;
: 94-98, 1996.
Artículo
en Inglés
| WPRIM
| ID: wpr-226468
ABSTRACT
It has been well known that the survivors of retinoblastoma are prone to have osteosarcoma. But the secondary tumor usually occurs in bilateral, hereditary type of retinoblastoma. We report one case of osteosarcoma in a survivor of unilateral, sporadic retinoblastoma. A fourteen year old male presented with a painfully swollen distal forearm of 2 month duration. He had enucleated his left eye 10 years ago due to retinoblastoma with no other adjuvant therapy. We managed him with our conventional protocol and identified deletion of Rb gene from his pathological specimen by using the PCR-RFLP method. This result is unusual for unilateral nonhereditable retinoblastoma and may suggest gene level change even in sporadic cases. And Rb gene study may be helpful for unilateral, sporadic retinoblastoma patient in detecting the possibility of late osteosarcoma.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Retinoblastoma
/
Imagen por Resonancia Magnética
/
Datos de Secuencia Molecular
/
Secuencia de Bases
/
Osteosarcoma
/
Genes de Retinoblastoma
/
Eliminación de Gen
/
Sobrevivientes
/
Cartilla de ADN
Tipo de estudio:
Guía de Práctica Clínica
Límite:
Adolescente
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
1996
Tipo del documento:
Artículo
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