Expression of E-cadherin and Clinical Correlation in Patients with Breast Carcinoma / 한국유방암학회지
Journal of Korean Breast Cancer Society
;
: 148-153, 2004.
Artículo
en Coreano
| WPRIM
| ID: wpr-226516
ABSTRACT
PURPOSE:
E-cadherin is a Ca (2+)-dependent cell adhesion molecule that plays an important role in normal growth and development via the mediation of homotypic, homophilic cell-cell interactions. Recent studies suggest that E-cadherin may also be important in neoplastic progression, particularly as a suppressor of invasion.METHODS:
To evaluate the expression of E-cadherin, according to the histopathological features and the relation between E-cadherin and prognosis in breast carcinoma, immunohistochemical staining, using mouse HECD-1 was performed for 66 cases of breast carcinoma.RESULTS:
The breast carcinomas showed loss or marked reduction of E-cadherin expression in 42 (63.6%) of the 66 cases. In a multivariate analysis, E-cadherin expression had no independent prognostic value, while the axillary lymph node status, tumor diameter, and TNM stage were independent prognostic factors. The results indicate that E-cadherin expression was related to several histological features in breast cancer, but had no independent prognostic value over standard prognostic factors. No significant correlation was found between E-cadherin expression and tumor size, stage, nuclear grade, lymph node status, histologic type, or hormonal status.CONCLUSION:
The loss or marked reduction of E-cadherin expression in breast carcinomas was not related to the prog nosis of the patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Mama
/
Neoplasias de la Mama
/
Cadherinas
/
Adhesión Celular
/
Análisis Multivariante
/
Negociación
/
Crecimiento y Desarrollo
/
Ganglios Linfáticos
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Coreano
Revista:
Journal of Korean Breast Cancer Society
Año:
2004
Tipo del documento:
Artículo
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