Concurrent Large Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Ascending Colon: A Case Report
Journal of the Korean Society of Coloproctology
;
: 157-161, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-226911
ABSTRACT
Large cell neuroendocrine carcinomas of the colon are rare and represent only a small percentage of all colonic endocrine tumors. Here, we report a case of a colonic large cell neuroendocrine carcinomas concurrent with a colonic adenocarcinoma. A 70-year-old man presented with acute abdominal pain. A spiral computed tomography scan of the abdomen revealed eccentric wall thickening on the ascending colon. An explorative laparotomy and a right hemicolectomy were performed. Grossly, two separated masses were observed in the proximal ascending colon. One was a 7.4 x 5.1 cm ulcerative fungating lesion, and the other was a 2.8 x 1.9 cm polypoid lesion. Microscopically, the ulcerative fungating lesion showed a well-differentiated neuroendocrine morphology with necrosis and increased mitosis. Most of the tumor cells had large, vesicular nuclei with eosinophilic nucleoli, variable amounts of eosinophilic cytoplasm, and immunoreactivity for chromogranin A and synaptophysin. The polypoid lesion was a well-differentiated adenocarcinoma that had invaded the submucosa. We diagnosed these lesions as a concurrent large cell neuroendocrine carcinoma and an adenocarcinoma of the ascending colon.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Úlcera
/
Adenocarcinoma
/
Dolor Abdominal
/
Sinaptofisina
/
Colon
/
Neoplasias del Colon
/
Carcinoma Neuroendocrino
/
Citoplasma
/
Tomografía Computarizada Espiral
/
Colon Ascendente
Límite:
Anciano
/
Humanos
Idioma:
Inglés
Revista:
Journal of the Korean Society of Coloproctology
Año:
2011
Tipo del documento:
Artículo
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