Stereological Comparison of the Effects of Pentoxifylline, Captopril, Simvastatin, and Tamoxifen on Kidney and Bladder Structure After Partial Urethral Obstruction in Rats
Korean Journal of Urology
;
: 756-763, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-227268
ABSTRACT
PURPOSE:
Limited studies have shown antifibrotic effects of pentoxifylline, captopril, simvastatin, and tamoxifen. No comparisons are available of the effects of these drugs on prevention of renal and bladder changes in partial urethral obstruction (PUO). MATERIALS ANDMETHODS:
The rats were divided into six groups (n=7). The sham-operated rats (group I) only underwent laparotomy and did not receive any treatments. The PUO groups (group II-VI) received normal saline (PUO+NS), pentoxifylline (100 mg/kg/d; PUO+PEN), captopril (35 mg/kg/d; PUO+CAP), simvastatin (15 mg/kg/d; PUO+SIM), or tamoxifen (10 mg/kg/d; PUO+TAM) by gavage for 28 days. Then, the volume and/or length of the kidney components (tubules, vessels, and fibrous tissue) and the bladder components (epithelial and muscular layers, fibrous tissue, fibroblast and fibrocyte number) were quantitatively evaluated on the microscopic sections by use of stereological techniques.RESULTS:
The volume of renal and bladder fibrosis was significantly ameliorated in the PUO+PEN group, followed by the PUO+CAP, PUO+SIM, and PUO+TAM groups. Also, the volume and length of the renal tubules and vessels and bladder layers were more significantly protected in the PUO+PEN group, followed by the PUO+CAP, PUO+SIM, and PUO+TAM groups.CONCLUSIONS:
Treatment of PUO with PEN was more effective in the prevention of renal and bladder fibrosis and in the preservation of renal and bladder structures.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pentoxifilina
/
Tamoxifeno
/
Obstrucción Uretral
/
Obstrucción del Cuello de la Vejiga Urinaria
/
Inhibidores de la Enzima Convertidora de Angiotensina
/
Captopril
/
Depuradores de Radicales Libres
/
Inhibidores de Hidroximetilglutaril-CoA Reductasas
/
Simvastatina
/
Modelos Animales de Enfermedad
Límite:
Animales
Idioma:
Inglés
Revista:
Korean Journal of Urology
Año:
2014
Tipo del documento:
Artículo
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