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A Case of Cryptococcal Pneumonia in a Rheumatoid Arthritis Patient after Tumor Necrosis Factor-alpha Antagonist Therapy / 대한류마티스학회지
The Journal of the Korean Rheumatism Association ; : 412-416, 2007.
Artículo en Coreano | WPRIM | ID: wpr-227630
ABSTRACT
Tumor necrosis factor-alpha (TNF-alpha) plays a important role in the pathogenesis of rheumatoid arthritis and Crohn's disease, TNF-alpha antagonist has been widely used for these disease, but it also plays a major role in cell mediated immunity. Cryptococcus neoformans, an encapsulated, ubiquitous environmental yeast, is pathogenic for humans, primarily those with compromised immune function. Cryptococcus neoformans is believed to be a facultative intracellular pathogen. We report a case of pulmonary cryptococcosis after chimeric anti-TNF monoclonal antibody therapy. No case has been reported in Korea for the best of our knowledge. A 66-year old woman was admitted because of severe cough. She was diagnosed to have rheumatoid arthritis 4 years ago and taken prednisolone and methotrexate. She was started on infliximab and received ten doses, the last dose being administered 6 weeks prior to above symptom. Chest PA and computed tomography of chest revealed multifocal consolidative lesions in both lungs. Pulmonary cryptococcosis confirmed by thoracoscopic lung biopsy tissue stained with Grocott-Gomori methenamine-silver (GMS). Initially the lung lesion responded to amphotericin B but leukopenia developed after 12 days of treatment. It was changed to fluconazole, then leukopenia and the pneumonia also improved. Physicians should remind pulmonary cryptococcosis in patients receiving TNF-alpha antagonist therapy.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neumonía / Artritis Reumatoide / Tórax / Levaduras / Biopsia / Prednisolona / Enfermedad de Crohn / Fluconazol / Anfotericina B / Metotrexato Límite: Anciano / Femenino / Humanos País/Región como asunto: Asia Idioma: Coreano Revista: The Journal of the Korean Rheumatism Association Año: 2007 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neumonía / Artritis Reumatoide / Tórax / Levaduras / Biopsia / Prednisolona / Enfermedad de Crohn / Fluconazol / Anfotericina B / Metotrexato Límite: Anciano / Femenino / Humanos País/Región como asunto: Asia Idioma: Coreano Revista: The Journal of the Korean Rheumatism Association Año: 2007 Tipo del documento: Artículo