Changes in biochemical markers of bone turnover and bone mineral density during pregnancy and postpartum in korean women / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
; : 166-179, 2009.
Article
en En
| WPRIM
| ID: wpr-227847
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE: To show the patterns of changes in biochemical markers of bone turnover and ultrasound bone mineral density (BMD) during pregnancy and postpartum in Korean women. METHODS: We conducted a prospective study between February 2004 and February 2005. Forty-one healthy singleton pregnant women were included. We used quantitative ultrasonography for BMD measurement which is advantageous to pregnant women because it is radiation-free and it provides very accurate BMD that correlates highly with BMD measured by conventional dual energy x-ray absorptiometry. We measured marker of bone resorption (beta-Crosslaps), bone formation [total alkaline phosphatase (ALP), osteocalcin (OC)], total calcium, phosphorus and parathyroid hormone (PTH) during and after pregnancy. RESULTS: During pregnancy, BMD slightly decreased in the third trimester. Bone resorption marker (beta-Crosslaps) increased steadily during pregnancy and immediate postpartum. Markers of bone formation (ALP, osteocalcin) increased from late pregnancy. Total calcium decreased slightly as bone resorption peaks in second trimester. PTH and phosphorus increased steadily throughout pregnancy and postpartum. CONCLUSION: Pregnancy is characterized by high bone turnover in Korean women with resorption preceding formation.
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Texto completo:
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Índice:
WPRIM
Asunto principal:
Osteogénesis
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Hormona Paratiroidea
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Fósforo
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Segundo Trimestre del Embarazo
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Tercer Trimestre del Embarazo
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Resorción Ósea
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Biomarcadores
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Absorciometría de Fotón
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Densidad Ósea
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Osteocalcina
Tipo de estudio:
Observational_studies
Límite:
Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Korean Journal of Obstetrics and Gynecology
Año:
2009
Tipo del documento:
Article