A Preliminary Report of Busulfan, Melphalan and Thiotepa or TBI-containing Bi-alkylator Chemotherapy as a Preparative Regimen for Allogeneic Bone Marrow Transplantation in Refractory or Relapsed Acute Leukemias / 대한암학회지
Journal of the Korean Cancer Association
; : 874-885, 1997.
Article
en Ko
| WPRIM
| ID: wpr-227990
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: We assessed the three-alkylator combination of busulfan, melphalan and thiotepa or TBI, melphalan and thiotepa conditioning for allogeneic stem cell transplantation in 7 adult patients with refractory or relapsed acute leukemias. MATERIALS AND METHODS: Six patients were transplanted for acute myeloid leukemia, one for acute lymphoblastic leukemia and included 5 of relapsed refractory, 2 of relapsed after first-BMT. All but 1 cases received G-CSF stimulated CD34+ allogeneic peripheral blood progenitor cells (PBPCs) in addition to stimulated allogeneic marrow. RESULTS: All patients except one engrafted (median time to ANC >0.5 10 (9)/L=11days, to platelets >30 X 10 (9)/L=14 days) successfully and complete remission was obtained in 6 patients. Grade I-II acute GVHD and controllable regimen-related toxicity especially oral mucositis (grade II-III) developed in all cases, but 2 patients including one second- allogeneic BMT patient expired early by transplant-related toxicity of hepatic or multiorgan failure along the course of sepsis. CONCLUSION: Although the observation period on these cases are limited, the data presented show that the combination of busulfan, melphalan and thiotepa is tolerable as a preparative regimen for allogeneic marrow transplantation in high-risk leukemic patients. We think that these encouraging results need to be confirmed in prospective studies in the future.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Células Madre
/
Estomatitis
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Médula Ósea
/
Busulfano
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Leucemia Mieloide Aguda
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Leucemia
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Factor Estimulante de Colonias de Granulocitos
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Trasplante de Médula Ósea
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Tiotepa
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Sepsis
Tipo de estudio:
Observational_studies
Límite:
Adult
/
Humans
Idioma:
Ko
Revista:
Journal of the Korean Cancer Association
Año:
1997
Tipo del documento:
Article