A Complex Chromosomal Rearrangement Involving 46,XX,t(1;7;16)(p32.1;q22;q13) in a Female with Recurrent Miscarriages After in vitro Fertilization
Laboratory Medicine Online
;
: 178-182, 2013.
Artículo
en Coreano
| WPRIM
| ID: wpr-228112
ABSTRACT
Balanced complex chromosomal rearrangements involving three or more chromosomes are often detected in phenotypically normal female patients with an adverse obstetric history. Here, we report a 32-yr-old phenotypically normal female with a history of multiple in vitro fertilization (IVF) failures and carrying a balanced complex chromosomal rearrangement involving chromosomes 1, 7, and 16. Cytogenetic analysis revealed the following complex karyotype 46,XX,t(1;7;16)(p32.1;q22;q13). The patient achieved a twin pregnancy after IVF, although no heartbeat was detected during the sixth gestational week checkup. Tissues from intrauterine fetal demise were tested for chromosomal analysis and revealed 46,XX,t(1;7;16)(p32.1;q22;q13)mat and 46,XY,der(1)t(1;16)(p32.1;q13),der(7)t(1;7) (p32.1;q22)mat. This case illustrates the importance of chromosomal analysis in infertile females or infertile females with multiple IVF failures. Therefore, it would be beneficial for patients visiting infertility clinics to undergo cytogenetic screening for complex chromosome rearrangements before further counseling and prenatal investigations.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fertilización In Vitro
/
Aborto Habitual
/
Tamizaje Masivo
/
Elevación
/
Consejo
/
Análisis Citogenético
/
Citogenética
/
Embarazo Gemelar
/
Infertilidad
Tipo de estudio:
Estudio pronóstico
/
Estudio de tamizaje
Límite:
Femenino
/
Humanos
/
Embarazo
Idioma:
Coreano
Revista:
Laboratory Medicine Online
Año:
2013
Tipo del documento:
Artículo
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