The Role of Oxidative Stress in Neurodegenerative Diseases
Experimental Neurobiology
;
: 325-340, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-228168
ABSTRACT
Oxidative stress is induced by an imbalanced redox states, involving either excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system. The brain is one of organs especially vulnerable to the effects of ROS because of its high oxygen demand and its abundance of peroxidation-susceptible lipid cells. Previous studies have demonstrated that oxidative stress plays a central role in a common pathophysiology of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Antioxidant therapy has been suggested for the prevention and treatment of neurodegenerative diseases, although the results with regard to their efficacy of treating neurodegenerative disease have been inconsistent. In this review, we will discuss the role of oxidative stress in the pathophysiology of neurodegenerative diseases and in vivo measurement of an index of damage by oxidative stress. Moreover, the present knowledge on antioxidant in the treatment of neurodegenerative diseases and future directions will be outlined.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oxidación-Reducción
/
Oxígeno
/
Enfermedad de Parkinson
/
Encéfalo
/
Especies Reactivas de Oxígeno
/
Estrés Oxidativo
/
Enfermedades Neurodegenerativas
/
Enfermedad de Alzheimer
Idioma:
Inglés
Revista:
Experimental Neurobiology
Año:
2015
Tipo del documento:
Artículo
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