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Comparison of oxidative stress markers in umbilical cord blood after vaginal and cesarean delivery
Obstetrics & Gynecology Science ; : 109-114, 2014.
Artículo en Inglés | WPRIM | ID: wpr-228433
ABSTRACT

OBJECTIVE:

The purpose of our study was to investigate the effect of the mode of delivery on the oxidant and antioxidant system in umbilical cord blood.

METHODS:

We performed gas analysis of umbilical venous blood and umbilical arterial blood immediately after delivery in 38 women; eighteen women had a vaginal delivery while 20 women delivered via cesarean section at over 37 weeks gestation. We examined lipid peroxide concentration by thiobarbituric acid reaction, protein carbonyl content by 2,4-dinitrophenylhydrazine reaction, and total antioxidant capacity by oxygen radical absorbance capacity assay.

RESULTS:

Lipid peroxide levels in umbilical venous blood were significantly higher in patients delivering by planned cesarean section (1.81 +/- 0.06 nmol/mg protein) than those with vaginal delivery (1.24 +/- 0.05 nmol/mg protein) (P < 0.05). Antioxidant capacity in umbilical venous blood was significantly higher in patients delivering by planned cesarean section (119.70 +/- 0.13 microM/microL) than those with a vaginal delivery (118.70 +/- 0.29 microM/microL) (P < 0.05). There was no significant difference in the carbonyl content of umbilical venous blood or in the lipid peroxide, carbonyl content, and total antioxidant capacity of umbilical arterial blood.

CONCLUSION:

Lipid peroxidation levels and antioxidant capacity in umbilical venous blood were higher in patients delivering by planned cesarean section than those with a vaginal delivery. Therefore, we propose that both the mother and neonate are exposed to higher oxidative stress during cesarean section delivery.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oxígeno / Cordón Umbilical / Peroxidación de Lípido / Cesárea / Estrés Oxidativo / Sangre Fetal / Madres Límite: Femenino / Humanos / Recién Nacido / Embarazo Idioma: Inglés Revista: Obstetrics & Gynecology Science Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oxígeno / Cordón Umbilical / Peroxidación de Lípido / Cesárea / Estrés Oxidativo / Sangre Fetal / Madres Límite: Femenino / Humanos / Recién Nacido / Embarazo Idioma: Inglés Revista: Obstetrics & Gynecology Science Año: 2014 Tipo del documento: Artículo