The Effects of Hemodynamic Findings on Development of Pulmonary Vascular Changes in Patients with Ventricular Septal Defect

ABSTRACT

Evlauation of pulmonary vascular changes and pre-and postoperative hemodynamic findings were performed in 25 patients who had ventricular septal defect associated with sevese pulmonary hypertension. Lung biopsy were done preoperatively in two patients and during operation in twenty three patients. Also the postoperative systemic and polmonary arterial pressure were obtained about 10-20 minutes after the cardiopulmonary bypass. The results were as follow 1) There was no relationship between the severity of pulmonary vascular changes(Health-Edwards classification) and the patients age(X2=4.4427, P=0.2175). 2) There was a good correlation between preoperative ratio of pulmonary to systemic vascular resistance(Rp/Rs) and ratio of pre-and postoperative pulmonary to systemic arterial pressure(r=0.4846, P<0.05). 3) There was a significant correlation between the degree of medial wall thickness and preoperative Rp/Rs(r=0.6535, P<0.005). 4) There was no correlation between perioperative hemodynamic findings and medial wall thickness in the patients aged below 2 years.