Complement-fixing abilities and IgG subclasses of autoantibodies in epidermolysis bullosa acquisita
Yonsei Medical Journal
;
: 339-344, 1998.
Artículo
en Inglés
| WPRIM
| ID: wpr-229297
ABSTRACT
Epidermolysis bullosa acquisita (EBA) is an autoimmune-mediated subepidermal bullous disease in which the target of the autoantibodies is type VII collagen, a major component of anchoring fibrils. The purpose of this study was to evaluate the complement-fixing abilities and IgG subclass distribution of autoantibodies in EBA, and to also attempt to investigate the relation between inflammation, complement fixation and IgG subclass distribution in EBA patients. Only 2 sera of 18 patients (11%) showed weak complement-fixing abilities. IgG1 and IgG4 were the most frequently and intensely stained IgG subclasses in EBA sera. We could not find any relationship between the clinico-pathologic types, complement-fixing abilities and IgG subclasses in EBA. These results suggested that complement activation may not be a key factor of bulla formation in EBA.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Autoanticuerpos
/
Proteínas del Sistema Complemento
/
Inmunoglobulina G
/
Epidermólisis Ampollosa Adquirida
/
Técnica del Anticuerpo Fluorescente
/
Persona de Mediana Edad
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Yonsei Medical Journal
Año:
1998
Tipo del documento:
Artículo
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