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Effect of selenium supplementation on activity and mRNA expression of type 1 deiodinase in mice with excessive iodine intake / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 302-308, 2006.
Artículo en Inglés | WPRIM | ID: wpr-229684
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of selenium supplementation on the selenium status and selenoenzyme, especially the activity and mRNA expression of type 1 deiodinase (D1) in mice with excessive iodine (EI) intake and to explore the mechanism of selenium intervention on iodine-induced abnormities.</p><p><b>METHODS</b>Weanling female BALB/c mice were given tap water or 3 mg/L of iodine or supplemented with 0.5 mg/L or 1.0 mg/L of selenium in the presence of excessive iodine for 5 months. Selenium status, thyroid hormone level, hepatic and renal D1 activity and mRNA expression were examined.</p><p><b>RESULTS</b>Excessive iodine intake significantly decreased the selenium concentration in urine and liver, and the activity of glutathione peroxidase (GSH-Px) in liver. Meanwhile, serum total T4 (TT4) increased while serum total T3 (TT3) decreased. Hepatic D1 enzyme activity and mRNA expression were reduced by 33% and 86%, respectively. Renal D1 enzyme activity and mRNA were reduced by 30% and 55%, respectively. Selenium supplementation obviously increased selenium concentration, activity of GSH-Px and Dl as well as mRNA expression of D1. However, increasing the supplementation of Se from 0.5 to 1.0 mg/L did not further increase selenoenzyme activity and expression.</p><p><b>CONCLUSION</b>Relative selenium deficiency caused by excessive iodine plays an essential role in the mechanism of iodine-induced abnormalities. An appropriate dose of selenium supplementation exercises a beneficial intervention.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Selenio / Tiroxina / Triyodotironina / Orina / Sangre / ARN Mensajero / Suplementos Dietéticos / Creatinina / Toxicidad Límite: Animales Idioma: Inglés Revista: Biomedical and Environmental Sciences Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Selenio / Tiroxina / Triyodotironina / Orina / Sangre / ARN Mensajero / Suplementos Dietéticos / Creatinina / Toxicidad Límite: Animales Idioma: Inglés Revista: Biomedical and Environmental Sciences Año: 2006 Tipo del documento: Artículo