Association between CYP1A1 gene polymorphism and intrahepatic cholestasis of pregnancy / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 70-72, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-229817
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between CYP1A1 genetic polymorphism and intrahepatic cholestasis of pregnancy (ICP) in Chengdu of China.</p><p><b>METHODS</b>MspI and Ile/Val genotypes of CYP1A1 gene were detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and allele-specific amplification-PCR (ASA-PCR) in a case-control study, including 100 cases of ICP and 100 controls.</p><p><b>RESULTS</b>There was no significant correlation between MspI polymorphism and ICP susceptibility (P>0.05). However, the Ile/Val+Val/Val genotypes of CYP1A1 significantly increased the risk of ICP (P=0.047, OR=1.768).</p><p><b>CONCLUSION</b>The Ile/Val polymorphism in exon 7 of CYP1A1 may be associated with the susceptibility of ICP in Chengdu. The MspI polymorphism of CYP1A1 is not associated with the risk of ICP in Chengdu.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
Complicaciones del Embarazo
/
Estudios de Casos y Controles
/
Colestasis Intrahepática
/
Citocromo P-450 CYP1A1
/
Predisposición Genética a la Enfermedad
/
Frecuencia de los Genes
/
Genética
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Embarazo
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2008
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS