Evaluating the applicability of MoM in second trimester maternal serum to screening for Down's syndrome in Jiangsu province / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 32-35, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-229826
ABSTRACT
<p><b>OBJECTIVE</b>To study the applicability of MultiCalc software to prenatal screening of Down's syndrome in Jiangsu province, China.</p><p><b>METHODS</b>The gestational age-specific median of maternal serum marker was calculated by means of regression method. Regression functions for adjustment of Multiple of the Median (MoM) by weight were established for our own population.</p><p><b>RESULTS</b>Before the adjustment by weight, the average level of alpha fetal protein(AFP) was 16% higher and the free beta-human chorionic gonadotrophin (beta-hCG) was 14% higher than those of the Caucasian in MultiCalc software respectively. But when the AFP and free beta-hCG results were converted to weight-adjusted MoM levels, the values were 0.99 and 1.02 respectively. The median of MoM of AFP and the free beta-hCG were 1.00 through the regression model of gestational age and weight adjustment.</p><p><b>CONCLUSION</b>There was no difference of average weight-adjusted MoM levels between the Jiangsu population and the Caucasian, and the MultiCalc software was applicable to maternal serum screening for Down's syndrome of Jiangsu.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Segundo Trimestre del Embarazo
/
Diagnóstico Prenatal
/
Valores de Referencia
/
Sangre
/
Peso Corporal
/
Programas Informáticos
/
Alfa-Fetoproteínas
/
China
/
Análisis de Regresión
/
Edad Gestacional
Tipo de estudio:
Estudio diagnóstico
/
Estudio de tamizaje
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Embarazo
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2008
Tipo del documento:
Artículo
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