Relationship between genetic polymorphism of MCP-1 and acute pancreatitis in Han population of Suzhou in China / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the relationship between monocyte chemoattractant protein-1 gene (MCP-1) -2518A/G polymorphism and acute pancreatitis (AP) in the Han population of Suzhou, China.</p><p><b>METHODS</b>The polymorphisms were detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The genotypes and allele frequencies of MCP-1 -2518A/G were calculated and analyzed in 101 AP patients including 78 mild AP (MAP) patients and 23 severe AP (SAP) patients, and 120 healthy individuals as control group.</p><p><b>RESULTS</b>The frequency of MCP-1 -2518 AA genotype in control group was significantly higher than that in SAP and MAP groups (P < 0.01). People with AG and GG genotypes had 5.896 times risk of developing MAP (P < 0.01, OR=5.896) compared with people with AA genotype. Subjects carrying G allele were at a 7-fold elevated risk for SAP (P < 0.05, OR=7.011) contrasted with subjects carrying AA genotype. However, no difference in AA genotypic distribution was noted between MAP and SAP groups (chi square=0.006, P=0.997). The frequency of G allele in healthy controls was obviously lower than that in MAP (P < 0.01, OR=0.318) and SAP groups (P < 0.01, OR=0.309). No difference of G allele frequency was found between SAP group and MAP group (P=0.623, OR=1.211).</p><p><b>CONCLUSION</b>The MCP-1 -2518 AA genotype of the population in Suzhou may be a protective genotype of AP. People with higher frequency of G allele is more likely to suffer from AP. Nonetheless, the genotype of AA and the frequency of G allele couldn't predict the risk of SAP.</p>