Association of -63A/C polymorphism of glutathione S-transferase M3 gene with essential hypertension in Chinese population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 582-585, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-229865
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the distribution of -63A/C polymorphism of human glutathione S-transferase M3(GSTM3) gene in Chinese Han population and the association of -63A/C polymorphism with essential hypertension (EH).</p><p><b>METHODS</b>-63A/C polymorphism of GSTM3 gene was examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 234 patients with EH and 328 healthy controls. The genotypes were confirmed partially by DNA sequencing.</p><p><b>RESULTS</b>The distribution of GSTM3 -63A/C was in Hardy-Weinberg equilibrium. The CC genotype frequency in EH group (6%) was significantly higher than that in control group(1.8%) (P < 0.05). After adjustment for age, body mass index, and other risk factors, the CC genotype was independently associated with hypertension (OR=3.447, 95%CI 1.19-7.63; P=0.04).</p><p><b>CONCLUSION</b>The GSTM3 -63A/C polymorphism was associated with EH in Chinese Han population, the C allele might be a risk factor for EH in Chinese Han nationality.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Polimorfismo de Longitud del Fragmento de Restricción
/
Secuencia de Bases
/
Etnicidad
/
Estudios de Casos y Controles
/
Análisis de Regresión
/
Polimorfismo de Nucleótido Simple
/
Pueblo Asiatico
/
Frecuencia de los Genes
/
Genética
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Factores de riesgo
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2007
Tipo del documento:
Artículo
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