Expression of BCL-10 in gastrointestinal mucosa-associated lymphoid tissue lymphoma / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 592-595, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-229922
ABSTRACT
<p><b>OBJECTIVE</b>To explore the significance of BCL-10 protein expression in the gastrointestinal mucosa-associated lymphoid tissue (MALT) lymphoma.</p><p><b>METHODS</b>Immunohistochemistry studies were performed using CD20, CD79a, CD3, CD45RO, CD23, CD5, CD10 monoclonal antibodies in 43 cases of gastrointestinal MALT lymphomas, including 25 indolent classical MALT lymphomas and 18 MALT lymphomas with large cell transformation. BCL-10 protein expression was assayed in the tumor cells.</p><p><b>RESULTS</b>In 25 low-grade MALT lymphomas, expression of BCL-10 was found in the nuclei in 10 cases, in both nuclei and cytoplasm 1 case, in cytoplasm 3 cases and no expression 11 cases. In 18 transformed MALT lymphomas, BCL-10 was expressed in the nuclei in 7 cases, in both nuclei and cytoplasm 1 case, in cytoplasm 2 cases, no expression 8 cases. The frequency of BCL-10 expression in nuclei was the highest (44.2%).</p><p><b>CONCLUSION</b>The frequency of BCL-10 expression in nuclei in the gastrointestinal MALT lymphoma is high, indicating that it may associate with the pathogenesis of this entity, and may be helpful to its diagnosis.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Inmunohistoquímica
/
Antígenos CD
/
Linfoma de Células B de la Zona Marginal
/
Proteínas Adaptadoras Transductoras de Señales
/
Proteína 10 de la LLC-Linfoma de Células B
/
Neoplasias Gastrointestinales
/
Metabolismo
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Hematology
Año:
2004
Tipo del documento:
Artículo
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