Comparative study on Jinghua Weikang Capsule and famotidine in treating duodenal ulcer / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To compare the effect and security of Jinghua Weikang Capsule (JWC) and famotidine in treating duodenal ulcer.</p><p><b>METHODS</b>Two hundred patients with duodenal ulcer were randomly divided into the treated group treated with JWC, 160 mg 3 times per day and the control group treated with famotidine 20 mg twice per day, both by orally taking before meal for 4 weeks, 100 cases in each group. Changes of symptom score, adverse reaction, helicobacter pylori (Hp) infection and endoscopic figure before and after treatment were observed.</p><p><b>RESULTS</b>The general remission rate and the ulcer healing rate in the treated group were equal to those in the control group respectively (both P > 0.05). Symptoms including belly ache, sour regurgitation and abdominal distension were ameliorated after therapy in both groups (all P < 0.05). The effect in relieving anorexia and eructation and Hp eradication rate were significantly higher in the treated group than those in the control group (all P< 0.05), while the incidence rate of adverse reaction in the treated group was remarkably lower than that in the control group (P < 0.05).</p><p><b>CONCLUSION</b>JWC is an effective and safe remedy in treating duodenal ulcer, especially for symptom amelioration and Hp eradication, so it is worthy of expanding clinically.</p>