Your browser doesn't support javascript.
loading
Effect of nimodipine on mechanisms of HL-60 cell apoptosis induced by cytarabine / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 72-75, 2007.
Artículo en Chino | WPRIM | ID: wpr-230330
ABSTRACT
The aim was to study the mechanisms of HL-60 cell apoptosis induced by nimodipine (NMDP) and cytarabine (Ara-C). The DNA fragment was detected by agarose gel electrophoresis. The expressions of bcl-2 and bax gene proteins related with apoptosis were investigated by immunohistochemistry. The results showed that HL-60 cell apoptosis rate had been increasing in the experimental groups compared with the control group since culturing 8 hours. The expression of Bcl-2 protein was lower and the expression of Bax protein was higher in the experimental groups than that in the control group, while ratio of bcl-2/bax was lower in the experimental groups than that in the control group. It is concluded that NMDP and Ara-C induce apoptosis of HL-60 cells, and the mechanism of apoptosis induced by them may down-regulate the expression of bcl-2 gene and up-regulate the expression of bax gene. The mechanism of HL-60 cell apoptosis induced by Ara-C and NMDP is probably associated with the down-regulation of Bcl-2 protein expression.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Nimodipina / Regulación Neoplásica de la Expresión Génica / Apoptosis / Células HL-60 / Resistencia a Antineoplásicos / Proteínas Proto-Oncogénicas c-bcl-2 / Citarabina / Sinergismo Farmacológico / Proteína bcl-X Límite: Humanos Idioma: Chino Revista: Journal of Experimental Hematology Año: 2007 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Nimodipina / Regulación Neoplásica de la Expresión Génica / Apoptosis / Células HL-60 / Resistencia a Antineoplásicos / Proteínas Proto-Oncogénicas c-bcl-2 / Citarabina / Sinergismo Farmacológico / Proteína bcl-X Límite: Humanos Idioma: Chino Revista: Journal of Experimental Hematology Año: 2007 Tipo del documento: Artículo