The expression of peroxiredoxin II in hepatocellular carcinoma and its significance / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 366-369, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-230595
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the mRNA and protein expressions of peroxiredoxin II (PrxII) in hepatocellular carcinoma (HCC) and their significance.</p><p><b>METHODS</b>HCC was induced by aflatoxin B1 (AFB1) in 6 tree shrews (Tupaia belangeri chinensis). The expression levels of PrxII mRNA and protein were detected by reverse transcriptase polymerase chain reaction (RT-PCR) and Western blot on HCC tissues and on their surrounding liver tissues (para-HCC). Biopsied liver tissues were taken before the HCC induction (pre-HCC) from the same animals and from a group of blank controlled animals that served as controls. Liver biopsy specimens from 18 cases of human HCC and from 17 healthy human volunteers were studied using the same methods.</p><p><b>RESULTS</b>The mRNA and protein expressions of PrxII in tree shrew HCC tissues were significantly higher than those in para-HCC and pre-HCC tissues, and also higher than those in the liver tissues from the control animals (all P < 0.05). The expression levels of PrxII mRNA and protein in human HCC tissues were also significantly higher than those in their para-HCC tissues and in the human normal liver tissues (P < 0.05).</p><p><b>CONCLUSION</b>PrxII might play an important role in hepatocarcinogenesis and might be used as a molecular target for HCC prevention and treatment.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Tupaiidae
/
Carcinoma Hepatocelular
/
Peroxirredoxinas
/
Genética
/
Hígado
/
Neoplasias Hepáticas
/
Neoplasias Hepáticas Experimentales
/
Metabolismo
Límite:
Animales
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Hepatology
Año:
2007
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS