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Activation of transcription factors induced by low concentration of N-methyl-N'-nitro-N-nitrosoguanidine / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 390-392, 2003.
Artículo en Chino | WPRIM | ID: wpr-231040
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of MNNG on some of the transcription factors such as NF- kappaB, CREB, AP-1 and c-Myc.</p><p><b>METHODS</b>The activities of these transcription factors were measured by transient transfection assay of SEAP vectors.</p><p><b>RESULT</b>The expressions of AP-1, CREB and NF- kappaB driven reporter genes were elevated for about 1.3, 1.4 and 1.3 times in MNNG-treated cells, respectively, as compared to untreated controls. However, the exposure of MNNG had no effect on the activity of c-Myc.</p><p><b>CONCLUSION</b>The activation of certain transcription factors might be involved in the process of untargeted mutation induced by low concentration of MNNG treatment.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Factores de Transcripción / Células Vero / Chlorocebus aethiops / FN-kappa B / Proteínas Proto-Oncogénicas c-myc / Proteína de Unión a Elemento de Respuesta al AMP Cíclico / Factor de Transcripción AP-1 / Toxicidad / Metilnitronitrosoguanidina / Mutación Límite: Animales Idioma: Chino Revista: Journal of Zhejiang University. Medical sciences Año: 2003 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Factores de Transcripción / Células Vero / Chlorocebus aethiops / FN-kappa B / Proteínas Proto-Oncogénicas c-myc / Proteína de Unión a Elemento de Respuesta al AMP Cíclico / Factor de Transcripción AP-1 / Toxicidad / Metilnitronitrosoguanidina / Mutación Límite: Animales Idioma: Chino Revista: Journal of Zhejiang University. Medical sciences Año: 2003 Tipo del documento: Artículo