Liver fibrosis indexes in nonalcoholic fatty liver disease / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To assess the clinical utility of liver fibrosis indexes determination in patients with nonalcoholic fatty liver disease.</p><p><b>METHODS</b>Liver fibrosis indexes of 79 patients with fatty liver, diagnosed by B ultrasonic echography, 37 patients with posthepatitic cirrhosis patients and 32 healthy subjects were determined.</p><p><b>RESULTS</b>The level of procollagen III(PC III), hyaluronic acid (HA), collagen IV(C IV), laminin (LN) in the fatty liver cases were significantly higher than those of healthy subjects (P<0.05 - 0.01), but lower than those in the liver cirrhosis cases (P<0.01). The difference of PC III, C IV, LN between the severe and early fatty liver cases was significant (P<0.05 - 0.01). Positive rate of these indexes was higher in severe cases.</p><p><b>CONCLUSION</b>There is a trend of liver fibrosis in severe fatty liver patients. Combined determination of liver fibrosis indexes may help the diagnosis of liver fibrosis in the fatty liver patients.</p>