Analysis of drug-resistant multi-loci mutation of P area of HBV genome in 32 patients with chronic hepatitis B / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 208-210, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-231148
ABSTRACT
<p><b>OBJECTIVE</b>In order to deeply understand the effects of nucleoside analogues to HBV DNA polymerase area, which initiate a state of drug resistance due to HBV genome mutation.</p><p><b>METHODS</b>Using PCR product direct sequencing method to test the gene sequence of P area of HBV genome of the patients who taking nucleoside analogues and showing signs of virologic breakthrough.</p><p><b>RESULTS</b>More resistance mutations can be find in HBV DNA polymerase area, which causing clinically cross drug resistance and multiple resistance.</p><p><b>CONCLUSION</b>We should choose higher genetic barrier for the initial treatment. And the patients long-term using of nucleoside analogues, should be regularly monitored serum HBV DNA level, in order for early detection of virological breakthrough and timely intervention.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Virología
/
Virus de la Hepatitis B
/
Reacción en Cadena de la Polimerasa
/
Genoma Viral
/
Hepatitis B Crónica
/
Farmacorresistencia Viral
/
Genética
/
Mutación
Tipo de estudio:
Estudio de tamizaje
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Experimental and Clinical Virology
Año:
2011
Tipo del documento:
Artículo
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