Treatment of rheumatoid arthritis by xinfeng capsule: an efficacy observation / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the curative effect of Xinfeng Capsule (XC) in treatment of rheumatoid arthritis (RA).</p><p><b>METHODS</b>Recruited were 80 active RA patients, who were randomly assigned to the normal control group and the treatment group, 40 in each group. All patients received the same routine anti-rheumatic treatment Methotrexate 10 mg per week; Diclofenac 50 mg when pain was obvious, twice daily. Patients in the treatment group took XC 3 tablets each time, thrice daily. All treatment lasted for 12 consecutive weeks. Serum iron (SI), serum ferritin (SF), transferrin (TRF); and RA disease activity index (DAS-28) were detected in all patients.</p><p><b>RESULTS</b>XC could improve HAQ, DAS-28, hypersensitive C reactive protein (hs-CRP), prostaglandins A (PGA), erythrocyte sedimentation rate (ESR), number of swelling joints, number of tender joints, and morning stiffness time in acute RA patients, showing statistical difference when compared with those of the control group (P < 0.01, P < 0.05). Compared with the control group, SI, SF, DAS-28, and TRF significantly decreased in the treatment group (P < 0.05).</p><p><b>CONCLUSION</b>XC could improve DAS-28, and SI reserve in patients with active RA, and lower DAS-28 related indicators.</p>