Progress in the studies on antitumor natural product ecteinascidin-743 / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 474-478, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-231904
ABSTRACT
The alkaloid ecteinascidin-743, isolated from the marine tunicate Ecteinascidia turbinata, binds to DNA and induces cytotoxic effects in several tumors. The drug is being codeveloped by Pharma Mar and Ortho Biotech. In May 2001 and October 2003, it was granted orphan drug status by the European Commission for soft tissue sarcoma and ovarian cancer, respectively. This paper reviews its research progress, including chemical synthesis, in vitro studies and mechanism of action, antitumor activity in vivo, toxicity, pharmacokinetics, and clinical studies.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Farmacocinética
/
Antineoplásicos Alquilantes
/
Tetrahidroisoquinolinas
/
Dioxoles
/
Toxicidad
/
Isoquinolinas
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2004
Tipo del documento:
Artículo
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