The in vitro and in vivo experimental models of erectile nerve regeneration / 中华男科学杂志
National Journal of Andrology
;
(12): 1059-1063, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-232015
ABSTRACT
Neurogenic erectile dysfunction (NED) caused by pelvic floor surgeries/radiation therapies and associated with Parkinsons disease and diabetes remains a challenging healthcare issue. To facilitate NED research we have developed in vitro and in vivo experimental models. The in vitro model comprises the isolation, culture and treatment of rat major pelvic ganglia (MPG), which then produce outgrowing neurites whose length and molecular composition are indicative of the neurotrophic effect of the treatment agent. Through this approach we have confirmed that the brain-derived neurotrophic factor (BDNF) promotes nerve regeneration by activating the JAK/STAT signaling pathway. This has been further established by our in vivo model, which involves the transection or cruch of cavernous nerves and treatment with BDNF.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pelvis
/
Pene
/
Técnicas In Vitro
/
Modelos Animales de Enfermedad
/
Ganglios
/
Disfunción Eréctil
/
Regeneración Nerviosa
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2007
Tipo del documento:
Artículo
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