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Inhibition of telomerase with hTERT antisense enhances TNF-alpha-induced apoptosis in prostate cancer cells PC3 / 中华男科学杂志
National Journal of Andrology ; (12): 723-726, 2007.
Artículo en Chino | WPRIM | ID: wpr-232076
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the inhibiting effect of telomerase with hTERT antisense on TNF-alpha-induced apoptosis in prostate cancer cells PC3.</p><p><b>METHODS</b>Antisense phosphorothioate oligodeoxynucleotide (AS PS-ODN) was synthesized and purified. Telomerase activity was measured by telomeric repeat amplification protocol (TRAP) and telomerase PCR-ELISA Kit, cell viability was determined by MTT assay, and cell apoptosis was observed by morphological method and determined by flow cytometry.</p><p><b>RESULTS</b>AS PS-ODN could significantly inhibit the telomerase activity and increase the susceptibility of TNF-alpha-induced apoptosis of PC3 cells.</p><p><b>CONCLUSION</b>Inhibition of telomerase with hTERT antisense can enhance TNF-alpha-induced apoptosis in prostate cancer cells.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Farmacología / Neoplasias de la Próstata / Ensayo de Inmunoadsorción Enzimática / Supervivencia Celular / Reacción en Cadena de la Polimerasa / Factor de Necrosis Tumoral alfa / Apoptosis / Telomerasa / Oligodesoxirribonucleótidos Antisentido Límite: Humanos / Masculino Idioma: Chino Revista: National Journal of Andrology Año: 2007 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Farmacología / Neoplasias de la Próstata / Ensayo de Inmunoadsorción Enzimática / Supervivencia Celular / Reacción en Cadena de la Polimerasa / Factor de Necrosis Tumoral alfa / Apoptosis / Telomerasa / Oligodesoxirribonucleótidos Antisentido Límite: Humanos / Masculino Idioma: Chino Revista: National Journal of Andrology Año: 2007 Tipo del documento: Artículo