The relationship between genetic polymorphism of metabolizing enzymes and the genetic susceptibility to lung cancer / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 1042-1045, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-232174
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between the gene polymorphism of metabolizing enzymes and the genetic susceptibility to lung cancer as well as to study the synergistic effects between smoking and the genes.</p><p><b>METHODS</b>A case-control study (case = 217, control = 200) was carried out to compare the frequent distribution of CYP1A1, 2E1, 2D6 and GSTM1 genotypes between the lung cancer group and the control group with a polymerase chain reaction-restriction fragment polymorphism (PCR-RFLP) method and to analyze the relationship between these genes and smoking.</p><p><b>RESULTS</b>GSTM1-null genotype frequency was 58.5% in the lung cancer group and 47.5% in the control group with significant difference (P = 0.02). The frequent distribution of CYP1A1, 2E1, 2D6 genotypes was not significantly different in the two groups (P > 0.05). Synergistic effects were found between smoking and GSTM1 but not between smoking and CYP1A1, 2E1, 2D6.</p><p><b>CONCLUSION</b>Smoking and GSTM1-null genotype seemed to be the risk factors of lung cancer. Those who carrying GSTM1-null genotype and smoking cigarettes were prone to suffer from lung cancer to become the high-risk population of the disease.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
Citocromo P-450 CYP1A1
/
Citocromo P-450 CYP2D6
/
Predisposición Genética a la Enfermedad
/
Genética
/
Glutatión Transferasa
/
Homocigoto
/
Neoplasias Pulmonares
Tipo de estudio:
Estudio observacional
Límite:
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Epidemiology
Año:
2004
Tipo del documento:
Artículo
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