Association of vitamin D receptor gene polymorphisms with Parkinson disease / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 13-16, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-232215
ABSTRACT
<p><b>OBJECTIVE</b>Vitamin D receptor (VDR) has been proposed as a candidate gene for susceptibility to Parkinson's disease (PD). This study was set to assess the association between VDR gene Apa I and Taq I polymorphisms and PD in a Chinese Han population.</p><p><b>METHODS</b>Two hundred and eighty five sporadic PD patients and 285 healthy controls were genotyped for the Apa I and Taq I polymorphisms in VDR gene using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.</p><p><b>RESULTS</b>No significant difference was detected in genotype or allele distribution of both Apa I and Taq I polymorphisms between PD patients and controls (P U+003E 0.05). No TT genotype for Taq I was found in the studied population. For Taq I, the distribution of genotype was significantly different between male PD patients and controls (U+03C7 2=4.187, P=0.032, OR=2.149, 95%CI 1.011-4.567), and the frequency of T allele was significantly higher in male PD patients than male controls (U+03C7 2=3.867, P=0.036, OR=2.064, 95%CI 0.989-4.307).</p><p><b>CONCLUSION</b>VDR gene Apa I polymorphisms are not associated with sporadic Parkinson's disease, but Taq I may be a risk factor for male PD.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Enfermedad de Parkinson
/
Polimorfismo Genético
/
Secuencia de Bases
/
Estudios de Casos y Controles
/
Factores Sexuales
/
Receptores de Calcitriol
/
Alelos
/
Estudios de Asociación Genética
/
Frecuencia de los Genes
/
Genética
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2013
Tipo del documento:
Artículo
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