Association study of NOS1 gene polymorphisms and schizophrenia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 459-463, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-232275
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association between nitric oxide synthase 1 (NOS1) gene polymorphisms and schizophrenia.</p><p><b>METHODS</b>Twenty eight tag single nucleotide polymorphisms (SNPs) of NOS1 in 382 schizophrenic patients and 448 healthy individuals sampled from Chinese Han population were analyzed by a Illumina GoldenGate Genotyping Assay.</p><p><b>RESULTS</b>One SNP (rs1520811) was found to be associated with schizophrenia, which however becomes negative after Bonferroni correction (P>0.05). Further analysis has failed to identify any association between particular haplotypes and the disease.</p><p><b>CONCLUSION</b>Our results did not support a significant association between NOS1 gene polymorphisms and schizophrenia.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Esquizofrenia
/
Haplotipos
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Óxido Nítrico Sintasa de Tipo I
/
Genética
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2012
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS