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Expression pattern of membrane type-1 matrix metalloproteinase in primary breast carcinomas / 南方医科大学学报
Journal of Southern Medical University ; (12): 94-97, 2016.
Artículo en Chino | WPRIM | ID: wpr-232504
ABSTRACT
<p><b>OBJECTIVE</b>To examine the expression pattern of membrane type-1 matrix metalloproteinase (MT1-MMP) in breast carcinomas.</p><p><b>METHODS</b>Forty-three breast cancer tissues were collected and examined for MT1-MMP protein and mRNA expressions using immunohistochemistry, semi-quantitative RT-PCR and in situ hybridization.</p><p><b>RESULTS</b>Immunohistochemistry of the breast cancer specimens showed MT1-MMP immunoreactivity on the cancer cell membrane. MT1-MMP mRNA was located in the stromal cells surrounding the breast cancer nest as shown by in situ hybridization. MT1-MMP mRNA expression was detected in all of the carcinomas, but its level was significantly lower in immunohistochemically negative specimens than in positive ones (0.547=0.0886 vs 0.759=0.0802, Plt;0.01).</p><p><b>CONCLUSION</b>MT1-MMP is very likely produced by stromal cells surrounding the breast cancer nest and anchored on the cell membrane after activation.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias de la Mama / ARN Mensajero / Inmunohistoquímica / Células Tumorales Cultivadas / Hibridación in Situ / Metaloproteinasa 14 de la Matriz / Genética / Metabolismo Límite: Femenino / Humanos Idioma: Chino Revista: Journal of Southern Medical University Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias de la Mama / ARN Mensajero / Inmunohistoquímica / Células Tumorales Cultivadas / Hibridación in Situ / Metaloproteinasa 14 de la Matriz / Genética / Metabolismo Límite: Femenino / Humanos Idioma: Chino Revista: Journal of Southern Medical University Año: 2016 Tipo del documento: Artículo