Early serological diagnosis of invasive aspergillosis in renal transplant recipients / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1659-1661, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-232551
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the clinical value of serum 1,3-beta-D-glucan (BG) and galactomannan (GM) detection for early diagnosis of invasive aspergillosis (IA) in patients after renal transplantation.</p><p><b>METHODS</b>Blood samples collected from 69 renal transplant recipients were divided into diagnosis group, clinical diagnosis group, suspected diagnosis group, and non-infected group for detection of serum BG and GM.</p><p><b>RESULTS</b>The mean serum levels of BG in the diagnosis group, clinical diagnosis group, and suspected diagnosis group were significantly higher than that in non-infected group (P<0.05). The sensitivity, specificity, and positive and negative predictive values of BG was 69.49%, 70%, 93.18% and 35.71% for IA diagnosis, respectively. The serum levels of GM in the 3 diagnosis groups were also significantly higher than that in the non-infected group (P<0.05) with the sensitivity, specificity, and positive and negative predictive values of 84.75%, 90%, 96.15% and 52.63% for IA diagnosis, respectively.</p><p><b>CONCLUSION</b>Increased serum BG and GM levels can serve as the evidence for early diagnosis of IA with a high diagnostic sensitivity and specificity in renal transplant recipients.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Aspergilosis
/
Sangre
/
Sensibilidad y Especificidad
/
Trasplante de Riñón
/
Diagnóstico Precoz
/
Beta-Glucanos
/
Diagnóstico
/
Mananos
Tipo de estudio:
Estudio diagnóstico
/
Estudio de tamizaje
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2015
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS