Folate receptor-mediated antitumor drugs / 药学学报
Acta Pharmaceutica Sinica
;
(12): 109-114, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-232588
ABSTRACT
Folate receptor (FR) is over-expressed in a variety of human cancers and it is seldom expressed or found in normal tissues. Therefore, folate receptor-mediated antitumor drugs can be targeted specially to the FR-positive tumor cells. This strategy improves the selectivity of drugs which may destroy the normal tissues in traditional chemotherapeutics. This review provides the delivery mechanism of FR-mediated antitumor drugs and highlights the novel folate-drug conjugates and their activities.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Portadores de Fármacos
/
Proteínas Portadoras
/
Química
/
Sistemas de Liberación de Medicamentos
/
Receptores de Superficie Celular
/
Línea Celular Tumoral
/
Receptores de Folato Anclados a GPI
/
Ácido Fólico
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2009
Tipo del documento:
Artículo
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