Synthesis and alpha-glucosidase inhibitory activity of N-(1,5-diaryl-3-pentone-1-yl)-4-aminobenzoic acid / 药学学报
Acta Pharmaceutica Sinica
;
(12): 48-55, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-232599
ABSTRACT
In order to find highly active antidiabetic lead compound, sixteen 4-aminobenzoic acid derivatives were designed and synthesized directly through Mannich reaction in the solution of ethanol at 15-35 degrees C with facile method, mild reaction condition and high yield (45%-90%). Fifteen of them are new compounds. Their structures were confirmed by 1H NMR, 13C NMR, IR, ESI-MS and HR-MS. Alpha-glucosidase inhibitory activity of these compounds indicated that most of these compounds possess the activity with the order 2c > 2b > 2h > 1a > 1f. The structure-activity relationship of these 4-aminobenzoic acid derivatives was also discussed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Relación Estructura-Actividad
/
Diseño de Fármacos
/
Estructura Molecular
/
Química
/
Ácido 4-Aminobenzoico
/
Alfa-Glucosidasas
/
Para-Aminobenzoatos
/
Inhibidores de Glicósido Hidrolasas
/
Hipoglucemiantes
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2009
Tipo del documento:
Artículo
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