Progress in the studies on small molecule IGF-1R inhibitors / 药学学报
Acta Pharmaceutica Sinica
;
(12): 979-984, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-232656
ABSTRACT
The importance of insulin-like growth factor 1 receptor (IGF-1R) signaling in malignant behaviour of tumour cells is well established. Inhibiting the activity of IGF-1R may result in striking apoptosis in malignant cells growing. IGF-1R antibodies which are currently in phase I and II clinical trials and several IGF-IR TKIs have preclinically been characterized. This review describes recent developments of small molecule tyrosine kinase inhibitors.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Piperazinas
/
Piridonas
/
Pirimidinas
/
Pirroles
/
Bencimidazoles
/
Transducción de Señal
/
Catequina
/
Química
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2008
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS