Characterization of microstructure of ibuprofen-hydroxypropyl-beta-cyclodextrin and ibuprofen-beta-cyclodextrin by atomic force microscope / 药学学报
Acta Pharmaceutica Sinica
;
(12): 969-973, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-232658
ABSTRACT
The microstructures of ibuprofen-hydroxypropyl-bets-cyclodextrin (IBU-HP-beta-CyD) and ibuprofen-beta-cyclodextrin (IBU-beta-CyD) were observed by atomic force microscope (AFM). The high resolving capability of AFM has the tungsten filament probe with the spring constant of 0.06 N x m(-1). Samples were observed in a small scale scanning area of 10.5 nm x 10.5 nm and 800 x 800 pixels. The original scanning images were gained by tapping mode at room temperature. Their three-dimensional reconstruction of microstructure was performed by G3DR software. The outer diameters of HP-beta-CyD and beta-CyD are 1.53 nm. The benzene diameter of IBU is 0.62 nm, fitting to the inner diameters of HP-beta-CyD and beta-CyD. The benzene and hydrophobic chain of IBU enter into the hole of cyclodextrin at 11 ratio. The results were evidenced by IR, X-ray diffraction and the phase solubility.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Espectrofotometría Infrarroja
/
Difracción de Rayos X
/
Química
/
Ibuprofeno
/
Sistemas de Liberación de Medicamentos
/
Microscopía de Fuerza Atómica
/
Analgésicos no Narcóticos
/
Beta-Ciclodextrinas
/
2-Hidroxipropil-beta-Ciclodextrina
/
Métodos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2008
Tipo del documento:
Artículo
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